Lois encourages Brian to submit his pilot script to a network. James Woods gets involved and things don’t exactly go according to Brian’s original plan. Meanwhile, Stewie has a bit of a mishap.

When Chris and Stewie go missing for several days, Lois is at her wit’s end until she sees a psychic who assures her they are safe. Even after the boys return home, Lois and Peter’s psychic obsession continues, and Peter takes it a step too far when he starts charging neighbors for his extrasensory perception. Meanwhile, Chris develops a crush on a girl at school.

Brian gets a job writing for a teen magazine. After trailing Meg around for research, he discovers that she has a secret boyfriend who’s in jail. When Brian attempts to inform the family of Meg’s secret life, it is revealed that her boyfriend has broken out of jail, and has been hiding in the Griffin’s house.

After hitting his head, Peter develops amnesia. He forgets everything, including his family and his friends. Lois takes extra care of Peter and tries everything to jog his memory and until he starts hitting on other women. Having had enough of his antics, Lois takes the kids and leaves.

After Peter throws Carter a wild bachelor party, he slips into a deep coma that not even Dr. House can bring him out of. Lois, now in control of Pewterschmidt Industries, is convinced by Peter to let him run the operation. Overcome by power, Peter fires the entire board. Carter eventually recovers, but realizes that it may be tough to get his company back.

After Brian accidentally kills another dog, and no one seems to care, he tries to convince everyone that they should value the life of a dog the same as a human. Meanwhile, Lois hires a maid who doesn’t listen to Peter.

Father doesn’t know best when Quagmire assumes responsibility for a baby Peter finds who looks just like him. Meanwhile, Stewie clones himself.

Stewie scores tickets to a Hannah Montana concert and discovers a surprising secret about the singer. Meanwhile, Chris tries to prove to the family that the Evil Monkey is real.

When Stewie and Brian discover that the guys who moved into Cleveland’s old house (guest stars Chevy Chase and Dan Aykroyd) are spies, they follow them on a mission to Russia. Meanwhile, Peter, Joe, and Quagmire start an improv group.

Lois gets tested for cancer and finds out she is of Jewish heritage, prompting the Griffins to convert to Judaism. At first, Peter takes to their newfound faith quite enthusiastically, but he changes his tune after receiving a visit from the ghost of his step-father.