Susan and Gabrielle go to extreme and shameless lenghts to top each other’s kids, whereas Bree invites Sam (guest star Sam Page) over for a family dinner. A party is thrown for Mrs. McCluskey after she beats cancer, and Lynette thinks there is more to Preston’s fiancée (guest star Helena Mattsson as Irina) than she’s letting on. Meanwhile, Katherine comes out of the closet, though not willingly.

Gabrielle and Angie head out to New York to track down Ana and Danny, and a chance encounter with supermodels Paulina Porizkova and Heidi Klum, Gaby’s former co-workers, leads the former top model to an unexpected revelation about herself. In the meantime, Mike tries to prove to Susan that he is a man with a capital “M” after he feels emasculated by her, and the Scavo family is surprised to see Preston (former regular castmember Max Carver) back from Europe… accompanied by a hot russian gold digger (guest star Helena Mattson as Irina). Bree discovers a surprising connection to her new employee (guest star Sam Page) and Katherine feels confused regarding her feelings towards Robin (guest star Julie Benz).

Gabrielle and Angie clash, and test each other’s parenting skills. In the meantime, Susan befriends a stripper named Robin (guest star Julie Benz) and takes her under her wing, whereas Tom and Lynette come to a disagreement regarding their new therapist (guest star Jane Leeves). Bree watches over Orson as she fears he may commit suicide.

Lynette balks at the idea of seeing a couples’ therapist. In the meantime, Katherine shows no intention to moving back onto the lane, whereas Gabrielle and Susan are determined to find out which of their kids is in the smartest math group at school, whereas Orson makes life harder for Bree and Angie disapproves of Danny’s new girlfriend.

Susan turns up the heat for Mike, whereas Lynette discovers Tom’s true intentions. Gabrielle is forced to examine feelings she’s suppressed regarding her heritage, and Bree learns it’ll be hard to undo the hurt she’s caused Orson. In the meantime, Ana is more determined to land Danny.

In the aftermath of the plane crash, the residents of Wisteria Lane reflect on what their lives might have been had they made different choices: Susan contemplates a life with Karl had he not walked out on her, and Bree considers life without Orson. Lynette thinks about a future with her unborn twins, whereas Gabrielle imagines her daughter Celia aspiring to become a superstar actress, and Angie ponders the consequences should her secrets be revealed.

Gabrielle and Lynette’s friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny’s vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.

In the wake of another unexpected attack, Nick decides the time has come for him and his family to move away from Wisteria Lane. In the meantime, Susan and Bree clash over the latter’s affair with Karl Mayer, whereas Gabrielle and Lynette clash over the latter’s pregnancy. Meanwhile, Katherine’s crazy schemes have brought Mike to a point where he can no longer put up with her, and a heated arguement between the two of them has shocking results.

Bree pretends to be Italian, provoking Italian siblings to hire her for a celebration, only to be faced with dire consequences: attending a dinner service at the Bolens. Gabrielle is having a tough time homeschooling Juanita, and she has her maid teach her, instead. Susan and a police officer fight about something from the past.

A childish side of Tom is evoked when Lynette discovers that he has been cheating on his tests, and that he also wants to lead the life of a frat-boy. Angie hides the truth about her mother, raising suspicion, yet again. Gabrielle is upset when Juanita is kicked out of the Thanksgiving pageant for swearing, but when she gets involved, it leads to expulsion. Orson unnoticeably pushes Bree into Karl’s arms.